Background Synthetic lethality (SL) occurs when an alteration in one gene renders cells vulnerable to inhibition of another, offering a strategy for targeted cancer therapy. PARP inhibitors represent the first clinically approved synthetic lethal therapy, and numerous additional candidates are now in clinical trials. U...
Metin Yazar, Christopher J. Lord, Colm J. Ryan· bioRxiv (Cold Spring Harbor...· 0 citations
A locally hosted web application that integrates orthology inference with Gene Ontology enrichment for comparative proteome analysis. It retrieves reference and non-reference proteomes from UniProt, runs OrthoFinder to infer orthogroups, explores orthogroup composition across species through interactive UpSet plots, an...
Carlos Vivas-Rodríguez, David Matallanas, Colm J. Ryan et al.· Zenodo (CERN European Organi...· 0 citations
A locally hosted web application that integrates orthology inference with Gene Ontology enrichment for comparative proteome analysis. It retrieves reference and non-reference proteomes from UniProt, runs OrthoFinder to infer orthogroups, explores orthogroup composition across species through interactive UpSet plots, an...
Carlos Vivas-Rodríguez, David Gomez Matallanas, Colm J. Ryan et al.· Zenodo (CERN European Organi...· 0 citations
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