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Corrado Santocanale

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#gene editing Review Open access Aug 2026

A survey of multi-targeting and off-targeting sgRNAs across five genome-wide CRISPR-Cas9 knockout sgRNA libraries with GuideRefine

It is confirmed that multi-targeting sgRNAs disproportionately impair cell fitness and that sgRNAs aligning to more than one location with a single mismatch can also reduce fitness, although to a lesser extent.

S. Bernard, M. Rainey, Corrado Santocanale et al. · 0 citations