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Curtis Hart

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#gene editing Open access Aug 2026

Scarless conditional sgRNAs via endogenous mascRNA processing enable rapid and temporally controlled genome editing

A scarless conditional sgRNA platform that combines Cre-loxP recombination with endogenous RNA processing to restore the native sgRNA architecture following induction is developed that preserves guide integrity and should be readily adaptable to time-resolved functional genomics and pooled screening applications.

Curtis Hart, Lovely Paul Solomon Devakumar, Khalid Saeed et al. · 0 citations