Author

D. Galasko

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Open access Oct 2026

Nuclear acetyl-CoA accumulation drives reversible RBP hyperacetylation and transcriptome-wide splicing shifts in age-equivalent Alzheimer’s disease neurons

Metabolic alterations and dysregulated alternative RNA splicing are central layers of Alzheimer’s disease (AD) pathogenesis, yet whether and to what extent these changes are mechanistically linked in adult human neurons in the aging brain remains unclear. To assess this, we generated induced neurons (iNs) by direct con...

Larissa Traxler, Oliver Borgogno, Kylie Champion et al. · bioRxiv · 0 citations

Jul 2026

Neurofibrillary tangle distribution in posterior cortical atrophy and typical early-onset Alzheimer's Disease

PCA is associated with a distribution of NFT pathology that coincides with early predominant visuospatial impairment in EOAD generally and may moderate degree of visuospatial impairment in EOAD regardless of clinical syndrome.

Denis S. Smirnov, Sophie M. Dickinson, Melanie F Estrella et al. · Free neuropathology · 0 citations

#protein folding Open access Aug 2026

Cerebrospinal fluid YWHAG:NPTX2 ratio predicts clinical severity and future phenoconversion in frontotemporal lobar degeneration

Frontotemporal lobar degeneration (FTLD) is a common cause of early-onset dementias marked by progressive declines in behavior, cognition, and/or movement. FTLD neuropathologies, including TDP-43 proteinopathies and primary tauopathies, do not have reliable fluid biomarkers for in-vivo diagnosis nor biomarkers that dir...

H. Oh, J. Downer, Connor D. Dietz et al. · bioRxiv · 0 citations