Background Vaccine-induced neutralising antibodies are a well-established correlate of protection against acquisition of COVID-19. Vaccine protection from severe COVID-19 remains high, although the role of neutralising antibodies and the contribution of other immune responses to protection from severe outcomes is less...
K. M. Elias, A. Mitchell, E. Stadler et al.· PLoS Medicine· 0 citations
A substantial benefit of vaccination for people on immunosuppressive therapy is shown, particularly after three vaccine doses and against severe outcomes, particularly after three vaccine doses and against severe outcomes.
E. Stadler, Shanchita R. Khan, K. M. Elias et al.· The Lancet Microbe· 0 citations
Neutralizing antibodies are a correlate of protection (CoP) of SARS-CoV-2 vaccine efficacy. However, data informing CoPs often explicitly exclude people on immunosuppressive therapies who are at an increased risk of symptomatic and severe COVID-19, delayed viral clearance, and death. Investigating the relationship betw...
E. Stadler, S. R. Khan, K. M. Elias et al.· medRxiv· 0 citations
Susceptibility to SARS-CoV-2 breakthrough infection in those with hybrid immunity is strongly associated with low levels of pre-existing antibody, but the diversity of immune markers associated with protection implies that additional benefits may be conferred by multi-pronged immunity.
A. Singanayagam, H. Wagstaffe, L. J. Slater et al.· medRxiv· 0 citations
Three commonly used types of neutralization assay were compared and strong correlations and significant differences in measured neutralization between the different assays were found, highlighting areas for more precise and harmonized terminology and particular assay elements that must be considered in efforts to harmo...
E. Stadler, F. Mordant, Matthew J. Gartner et al.· Journal of Virology· 0 citations
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