High-resolution comparative genomics of RB1 mutations in gastric and hepatocellular carcinoma: Functional insights through the TP53 co-mutational landscape
Retinoblastoma protein (pRb) is a critical tumor suppressor that regulates the cell cycle and maintains genetic stability. While mutations in the retinoblastoma 1(RB1) gene are well-documented in gastric adenocarcinoma (GAC) and hepatocellular carcinoma (HCC), the genomic landscape in Middle Eastern populations remains...