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Author

D. Ofengeim

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Open access Sep 2026

Anti-CD40L prevents meningeal B cell aggregates and mitigates progressive autoimmune encephalomyelitis.

Anti-CD40L treatment may be an effective intervention to mitigate progressive immunopathology associated with meningeal TLS, and modulates and likely silences other CD40-dependent antigen-presenting cells in the CNS, including myeloid cells and astrocyte subsets.

Sofia Tyystjärvi, Diego Ruiz Navarro, Leni-Mihaela Kulisch et al. · 0 citations
Open access Aug 2026

Microglia drive demyelination via multiple sclerosis antibodies and BTK signaling

Inhibition of Bruton’s tyrosine kinase (BTK) limited microglial transcriptional changes and prevented myelin loss following microglial envelopment and support BTK inhibition as a therapeutic strategy to prevent demyelination by modulating microglia behavior.

Lindsay A. Osso, Helena J. Barr, Michael E. Stockton et al. · 0 citations

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