D. Russell

Beyond Structure: Protein and Solution Dynamics Shape Ligand-Binding Thermodynamics

Regulation of a Classical Allosteric Molecular Machine by an Intrinsically Disordered Domain: the C-termini of GroEL

A regulatory role is identified for the conserved, intrinsically disordered C-terminal tails of GroEL, one of the best-studied ATP-dependent chaperones, to reveal how the conformational properties of an intrinsically disordered element can be exploited to optimize the energetic efficiency and functional timing of a lar...

Dynamics of the Myoglobin/Heme Complex: A Limited Proteolysis Perspective

The dynamics and stabilities (i.e., physicochemical properties) of proteins and protein complexes are dictated by the solution environment. Changes in the solution environment may alter the distribution of states present in solution (i.e., the free-energy landscape) and thus their physicochemical properties. This wor...

Solution Phase Protein Dynamics: Influences of ESI Buffers on Hydration

Buffers are commonly selected for their compatibility with biochemical measurements or their specific capabilities, yet buffer interactions with proteins and the surrounding water can actively reshape protein activity, structure, and dynamics. Here, we compare the influences of three widely used electrospray ionization...