Da Qian

Epigenetic regulation of NLRP3 by ACLY–PLAC8 axis sustains metabolic adaptation in triple-negative breast cancer

Cell metabolism is intricately interconnected with various pathological processes, including metabolic disorders, chronic inflammation, and tumor progression. Dysregulated lipid metabolism can result in mitochondrial dysfunction and excessive reactive oxygen species accumulation, which are well-established triggers f...

Targeted Lysosomal Degradation of Extracellular and Membrane Proteins: From Receptor Hijacking to Programmable Endolysosomal Routing

ABSTRACT Lysosome‐targeting chimeras (LYTACs) have emerged as a strategy for eliminating secreted, extracellular, and plasma‐membrane proteins by redirecting them to the endolysosomal system. By coupling target recognition to receptor‐mediated uptake, LYTACs exploit endogenous trafficking pathways to access disease‐ass...

Nitrogen-doped carbon nanodots-based "off-on" fluorescent sensor for the detection of breast cancer-derived exosomes and early diagnosis.

A Single‐Amino‐Acid Ligand for LAT1: A Minimalist and Modular Platform for Lysosome‐Targeted Degradation of Membrane Proteins

This work establishes a synthetically accessible, truly modular, and tumor‑selective degradation platform driven by a single amino acid, offering a streamlined alternative to existing lysosome‑targeting technologies.

Dual-mode fluorescence and UV-vis aptasensor for hepatocellular carcinoma detection using magnetic separation

A dual-mode aptasensor based on magnetic separation with a sequential signal conversion mechanism is developed for sensitive and specific detection of HepG2 cells, exhibiting high specificity for HepG2 over other tumor cells.