TL;DR
A dual-mode aptasensor based on magnetic separation with a sequential signal conversion mechanism is developed for sensitive and specific detection of HepG2 cells, exhibiting high specificity for HepG2 over other tumor cells.
A ratiometric fluorescence nanosensor using dual-emission CdTe quantum dots (R-QDs) for sensitive detection of APE1, a DNA repair enzyme and cancer biomarker, successfully detected APE1 in breast cancer cell lysates with good linearity and recovery rates.
A dual-mode colorimetric–photothermal LFIA platform was successfully constructed for the detection of thrombosis-related biomarkers, including thrombomodulin and α2-plasmin inhibitor–plasmin complex, in clinical serum samples, enhancing analytical sensitivity and reliability.
It is shown that transforming a molecular ECL luminophore into a colloidal nanoprobe can increase its cellular uptake as well as enhance its application potential via both fluorescence and ECL.
The rapid and accurate detection of chlorpyrifos (CPF), a widely used pesticide in agricultural products, is crucial for food safety assurance. While traditional methods like HPLC and GC-MS are accurate, they remain costly, slow, and lack portability. Herein, an ultrasensitive magnetic biosensing platform was developed...
A dual-mode photothermal/colorimetric aptasensor using CD63 aptamer-functionalized core-shell AuPt nanozymes for detecting GC-related CD63-positive exosomes in serum samples and providing a dual-mode tool for quantitative GC-related exosome analysis and preliminary extracellular vesicle monitoring is developed.
Self-validated bioanalytical systems based on mechanistically orthogonal dual-mode transduction have attracted considerable interest, yet their development critically depends on multifunctional heterostructure materials that simultaneously enable efficient charge separation and well-resolved dual-emission output. Herei...
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