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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Daniel A. Sprague

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2 papers indexed here

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#protein folding Open access Sep 2026

BI-TfR1 CapX rapidly transits the blood-brain barrier for efficient, low-dose gene delivery throughout the CNS

BI-TfR1 CapX is described, a human transferrin receptor (TfR1)-binding AAV capsid that, after a low intravenous dose in adult humanized TFRC mice, transduced more than 80% of cortical and spinal neurons and ∼60% of cortical astrocytes, with reduced distribution and expression in several peripheral tissues relative to A...

Ken Y. Chan, Chin-Yen Lin, Qin Huang et al. · 0 citations
Open access Jul 2026

Phenotypic screening for small molecules that lower PrP in cultured cells

Findings highlight the challenges associated with mechanism-agnostic phenotypic screening for PrP-lowering compounds and support prioritizing compounds with known mechanisms of action and support prioritizing compounds with known mechanisms of action.

Jeannine A. Frei, A. Reidenbach, Leo Xu et al. · 0 citations

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