Author

Daniel E. Bauer

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Open access Oct 2026

DNA replication stress redistributes the histone methyltransferase G9a and activates lineage-specific gene expression

Perturbations that cause DNA replication stress can induce lineage-specific changes in gene expression. Specifically, DNA replication stress activates primed loci in euchromatin that are epigenetically silenced, but the mechanism linking stalled replication forks to the activation of distal genes remains unknown. Using...

Gillian E. Oaks, Brian T. Do, Emma M. Jakubicka et al. · bioRxiv · 0 citations

#gene editing Open access Aug 2026

Analysing long-read CRISPR experiments with CRISPRLungo.

This work presents CRISPRLungo, a computational pipeline specifically designed for long-read amplicon sequencing of gene edited samples that incorporates unique molecular identifier-based error correction and statistical filtering to distinguish true editing events from background noise, enabling robust detection of sm...

Gue-Ho Hwang, Benjamin Vyshedskiy, Timothy M. Barry et al. · Nature Biomedical Engineerin... · 0 citations