Exposure of cells to prions induces prion strain dependent changes in mitochondrial redox state and respiration.
During initial prion infection, PrPSc drives mitochondrial dysfunction in a manner that is both strain dependent and independent of PrPC expression, while persistent prion infection increases mitochondrial sensitivity to cellular stress.
Daniel Shoup, L. Varner, B. Race et al.
· Journal of Cell Science · 0 citations