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Author

David B. Ascher

3 papers indexed here

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Jul 2025

Tracking breast cancer progression using Methylscape

Cancer progression is intricately driven by epigenetic reprogramming, where aberrant DNA methylation patterns reshape gene regulation and cellular phenotypes. These alterations include promoter hypermethylation of tumour suppressor genes and global hypomethylation, collectively fuelling oncogenesis and disease advancem...

Zhen Zhang, E. Ahmed, Nicolas Constantin et al. · 0 citations
Open access Aug 2026

Copine-6 integrates calcium, phosphoinositide and Rab11 signals to coordinate glutamate receptor recycling

Endosomal trafficking is a major pathway that delivers cell-surface proteins, including glutamate receptors, to support neurotransmission and normal brain functions. Activity-dependent insertion of glutamate receptors is essential for synaptic plasticity, learning and memory. Copine-6 is a neuronal-specific calcium (Ca...

J. A. Tan, Ana Batallas-Borja, Mintu Chandra et al. · 0 citations
#gene editing Review Open access Sep 2026

LDLR variant classification through activity-normalized prime editing screening

Activity-normalized prime editing provides a scalable framework for LDLR variant classification that substantially expands the proportion of variants with evidence for genetic diagnosis and reveals novel biology with therapeutic relevance.

P. Zhou, Minja Velimirovic, Tian Yu et al. · 0 citations

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