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Author

David Ferreiro

2 papers indexed here

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#protein folding Open access Sep 2026

Evolution of the SARS-CoV-2 Main Protease Under Fitness Constraints Imposed by Folding Stability and Activity.

Overall, SARS-CoV-2 Mpro evolution is strongly constrained by structural and functional requirements, supporting the suitability of this protein as an effective antiviral target and suggesting that incorporating viral evolutionary dynamics may help inform the design of therapeutic strategies with improved long-term rob...

David Ferreiro, Miguel Arenas · 0 citations
#graph neural networks Open access Sep 2026

Heterogeneous graph neural networks with biological prior knowledge for interpretable drug repurposing in triple-negative breast cancer

Drug repurposing offers a cost-effective path to new therapies for triple-negative breast cancer (TNBC), a subtype with limited targeted treatment options. We present PRECISION, a framework integrating transcription factor (TF) regulatory networks, protein-protein interactions, and drug-target edges into a heterogeneou...

Carlos Fernandez-Lozano, David Ferreiro, Patricia V.-del-Río · 0 citations

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