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Derek N. Woolfson

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#protein folding Open access Oct 2026

Exploring the Design Space of 3 10 -helical Bundles using Non-canonical Amino Acids

Steric constraints and favored hydrogen-bonding patterns result in peptides and proteins based on α-amino acids being largely confined to α-helical and β-strand secondary structures. Although stand-alone 310 helices can be stabilized by incorporating α,α-disubstituted amino acids such as amino-isobutyric acid (Aib, U),...

Xiyue Leng, Jonathan Clayden, Derek N. Woolfson · bioRxiv (Cold Spring Harbor... · 0 citations

#protein folding Open access Sep 2026

Exploring the Design Space of 310-helical Bundles using Non-canonical Amino Acid

Discussion and ConclusionThe (ELUULK) 4 3 10 -helical bundle displays strongly position-dependent mutational tolerance.Surface residues can be readily substituted while preserving the 3 10 architecture, whereas the interfacial Aib positions and hydrophobic core impose much tighter geometric constraints.Computational an...

Xiyue Leng, Jonathan Clayden, Derek N. Woolfson · Proceedings of the 38th Euro... · 0 citations