Figure 6 from Targeting PRMT5 Inhibitor–Induced Adaptation in Pancreatic Cancer with the RBM39 Degrader Indisulam
PRMT5 and RBM39 inhibition regulate DNA repair and metabolic pathways. A, Workflow of the RNA-seq approach: PSN1 cells were treated with DMSO as the vehicle control, 4 nmol/L JNJ-64619178, 200 nmol/L indisulam, or the combination of 4 nmol/L JNJ-64619178 and 200 nmol/L indisulam for 48 hours, mRNA was isolated, and mRN...
Valentina Spielmann, Jonas Buchloh, Selen Selcen et al.
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