Author

Dongwei Lin

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#gene editing Review Open access Oct 2026

Next-generation tumor organoids: a functional integration framework for advancing precision oncology

Tumor organoids are three-dimensional (3D), self-organizing cultures that have become a central experimental platform in cancer research and translational medicine. Their value lies in preserving genetic heterogeneity, reproducing patient-specific phenotypes, and supporting functional drug sensitivity testing. Yet co...

Wen-Wen Zhao, Ling Huang, Yi-Yung Cheng et al. · Journal of Translational Med... · 0 citations

Open access Jul 2026

Unraveling the roles of DKK1 and S100P in pancreatic ductal adenocarcinoma: Insights from machine learning, single-cell/spatial transcriptomics, and functional validation

Functional assays confirmed that DKK1 and S100P significantly promote PDAC cell proliferation and migration in the tumor microenvironment.

Yanzhao Mao, Yu-Qi Zhang, Yu-Peng Zhang et al. · Translational Oncology · 0 citations

Review Open access Aug 2026

Interconnected roles of cellular senescence and the immune microenvironment in tumor progression: from pan-cancer mechanisms to glioblastoma implications

This review systematically examines the molecular mechanisms of cellular senescence, with emphasis on the intrinsic logic governing bidirectional remodeling between senescent cells and the immune microenvironment, to provide a new theoretical foundation for next-generation precision cancer immunotherapy.

Wen-Wen Zhao, Pengfei Zhang, Li-Xin Li et al. · Cell Death Discovery · 0 citations