Douglas A. Whittington

Figure 4 from TNG961 Is a Selective Oral HBS1L Molecular Glue Degrader for the Treatment of FOCAD-Deleted Cancers

TNG961 induces potent, selective CRBN-dependent degradation of HBS1L. A, Endogenous HBS1L degradation and PELO destabilization measured by Western blot after 24 hours of treatment with TNG961 in the indicated cell lines. The top dose was 10 µmol/L, tested as a 9-point, 3-fold dilution series. Representative images are...