Drew Weissman

Dual-Antigen CCHFV Vaccine Induces Neutralizing Immunity and Protection Against Lethal Challenge

It is demonstrated that systematic antigen screening combined with genetic vaccine platforms can identify a potent multi-antigen CCHF vaccine candidate and induced Gc-specific neutralizing antibodies and T-cell responses against both NP and Gc.

Functional Improvement of dystrophic muscle by utrophin gene editing

Protective pan-betacoronavirus neutralizing antibodies by vaccination

These findings provide proof-of-concept that epitope-focused nanoparticle immunogens can target partially occluded, immunoquiescent bnAb epitopes, laying the groundwork for pan-betacoronavirus vaccines that provide broad protection and strengthen pandemic preparedness.