A new series of benzo[h]quinoline-based derivatives was synthesized using a thiocarbohydrazone scaffold as a versatile intermediate for the construction of diverse nitrogen- and sulfur-containing heterocycles, including tetrazine, thiadiazole, triazole, pyrazole, and thiadiazine motifs. These structural variations were...
E. El-Helw, Abeer M. El-Naggar, Mahmoud Kamal et al.· RSC Advances· 0 citations
Despite advances in targeted cancer therapies, drug resistance and off-target toxicity remain major challenges, underscoring the need for new multi-targeted agents with improved selectivity. The present study evaluated the anticancer potential of newly synthesized hexahydro-1,8-acridinedione derivatives featuring strat...
E. El-Helw, S. Hammad, Hassan A. Khatab et al.· Scientific Reports· 0 citations
These findings highlight pyrazole-based scaffolds as promising antimicrobial candidates with favorable biological profiles, providing a strong basis for further structural optimization.
E. El-Helw, Selwan Hamed, A. El-ziaty et al.· Scientific Reports· 1 citation
Biochemical evaluation of triazinone 3 revealed significant reductions in acetylcholinesterase activity and in total protein, carbohydrate, and lipid contents compared with untreated larvae, indicating that larval mortality was accompanied by cholinergic disturbance and depletion of metabolic reserves.
E. El‐Helw, Mahmoud Kamal, Eslam M. Hosni et al.· Bioorganic chemistry (Print)· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
