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#gene editing Open access Oct 2026

Transcription factor TBX2 is a key regulator of vascular calcification.

BACKGROUND AND AIMS Vascular calcification predicts cardiovascular mortality more strongly than traditional risk factors, yet its molecular basis remains poorly understood. The burden is greatest in chronic kidney disease (CKD), where disordered mineral metabolism accelerates arterial mineral deposition. METHODS Cros...

Shen Li, Hong-Bo Liu, Su-Jin Lee et al. · 0 citations
Open access Jul 2026

Single-cell spatial mapping of human kidney development implicates the microenvironment in guiding cell fate decisions

This analysis revealed unrecognized plasticity, showing that cell fate established during early patterning can be later revised and provides a potential mechanism for how cell fate is robustly established in complex patterned tissues.

Jonathan Levinsohn, Samuel Grindel, Bernhard Dumoulin et al. · 2 citations

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