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Author

E. Holzbaur

3 papers indexed here

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#gene editing Open access Sep 2026

Pathogenic KIF1A variants differentially disrupt axonal trafficking and impede synaptic development

The nervous system relies on billions of neurons connected through trillions of synapses to support vital functions. Despite the importance of this synaptic network, cellular mechanisms dictating synapse formation during human neurodevelopment remain unclear. Long-distance trafficking by the microtubule motor KIF1A is...

Jayne Aiken, Carris Borland, Nicolas Marotta et al. · 0 citations
Review Open access Sep 2026

Mitophagy in neuronal health and disease: from mechanisms to neurodegeneration

Regulation of mitochondrial health is critical for maintaining cellular homeostasis in the nervous system. Damaged mitochondria can have detrimental effects on neuronal health and are thought to be key contributors to the progression of neurodegenerative disorders including Parkinson’s disease and amyotrophic lateral s...

Bishal Basak, Julia F. Riley, Neha M. Nataraj et al. · 0 citations

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