In this study, we present the largest rare coding variant association study of schizophrenia to date, with 87,959 schizophrenia cases and 150,587 controls. We identify 16 genes at exome-wide significance: SETD1A, ZMYM2, HERC1, RB1CC1, SCAF1, XPO7, SP4, FYN, PPP3CA, CUL1, HDAC9, JARID2, ATP9A, PTK2, STAG1, and SCN2A, an...
J. Sealock, C. Dowd, Calwing Liao et al.· bioRxiv· 1 citation
Together, these results implicate a constellation of rare variants that map onto neuronal biology and demonstrate that diverse global populations converge on shared genetic signals underlying BD risk.
Calwing Liao, Robert Ye, J. Sealock et al.· medRxiv· 0 citations
Context Long COVID is characterized by persistent symptoms ≥ 3 months after acute SARS-CoV-2 infection. To date, the underlying pathophysiology is unclear. Objective To characterize the immune and metabolic features of Long COVID and the potential role of viral persistence in adipose tissue. Design Case-control, cross-...
Ivette F. Emery, Seynt Jiro Sahagun, Elizabeth R. M. Zunica et al.· Frontiers in Endocrinology· 0 citations
OBJECTIVE
We investigated prospective associations between mental health conditions (depression, anxiety, and post-traumatic stress disorder, PTSD) and recurrent acute care use among patients with systemic lupus erythematosus (SLE).
METHODS
Within All of Us Research Program (version 8), a US-wide cohort of adults enr...
K. Costenbader, Jeong Yee, Hong-Shu Guan et al.· Journal of Rheumatology· 0 citations
Early herpesvirus-directed antibody responses following SARS-CoV-2 infection exhibit distinct virus- and isotype-specific patterns associated with long COVID, suggesting that heterogeneity in long COVID may be linked to differential herpesvirus-directed humoural immune responses that emerge early after infection.
Ananya Choudhury, M. Burry, W. Kwon et al.· EBioMedicine· 0 citations
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