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Open access Aug 2026

Microglia activation by derepression of endogenous retroviruses drives inflammation and cellular senescence.

Aging-associated loss of chromatin compaction is linked to derepression of retrotransposable elements (RTEs) in mouse and human tissues. Whether such RTE transcription contributes to the microglia activation that is common in aged brains is unknown. Here, we show that DAXX, a histone chaperone and RTE repressor, is dow...

Xin Yan, Christina Georgopoulou, Hang-Mao Lee et al. · 0 citations
Review 2026

Microglia-centered cellular crosstalk in neurodegeneration.

This chapter focuses on the diversification of neurodegenerative CNS microglial states, the interaction of microglia with neurons, glial cells, adaptive immune cells, and the vasculature, and how this framework provides a basis for therapeutic strategies aimed at modulating, replacing, or reprogramming microglia in neu...

Hao Huang, E. Mass · 0 citations

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