Microglia-centered cellular crosstalk in neurodegeneration.

Altered microglial communication in brains with Alzheimer’s Disease pathology

It was found that AD was characterized by altered microglial composition and rewiring of intercellular communication, including disease-specific signaling pathways and distinct interaction hubs.

Microglia and neuroinflammation: An in‐depth analysis from functional diversity to disease mechanisms

Abstract Background Microglia are essential regulators of central nervous system homeostasis and participate in immune surveillance, inflammatory regulation, phagocytosis, metabolic adaptation, and tissue repair. Recent single cell and spatial omics studies have revealed extensive microglial heterogeneity, challenging...

Microglia in Alzheimer's disease: Insights into disease progression and therapy.

Molecular signaling pathways shaping astrocyte–microglia crosstalk in health and disease

The molecular mechanisms underlying astrocyte–microglia molecular crosstalk in physiological and pathological contexts are summarized, with particular emphasis on the secreted mediators that dynamically reprogram glial signaling networks.

“Stand by me”: astrocyte–microglia crosstalk in central nervous system development, homeostasis, injury, and disease

During central nervous system (CNS) development, astrocytes and microglia arise from distinct embryonic origins; however, during early development, both cell types coordinately participate in brain circuit formation and neuronal network establishment. Later, in the healthy adult CNS, astrocytes are known to play essent...

From metabolism to neurodegeneration: how microglial functional reprogramming drives neurodegenerative diseases

A microglial immunometabolic trajectory framework is proposed in which metabolic states are viewed as branching and potentially reversible determinants of cellular function rather than fixed stages of a universal disease pathway.