Abstract DNA methylation alterations are early and stable hallmarks of cancer and represent promising biomarkers for non-invasive detection using circulating cell-free DNA (cfDNA). However, current computational approaches often model DNA sequence and methylation features separately and struggle to capture complex read...
Maryam Yassi, Mark Ezegbogu, E. Rodger et al.· Briefings in Bioinformatics· 0 citations
Abstract Background Non–small cell lung cancer (NSCLC) is the leading cause of cancer-related mortality worldwide and continues to have poor survival outcomes, with most patients diagnosed at advanced stages of disease. In New Zealand, NSCLC contributes substantially to cancer inequities, with Māori communities experie...
Rajiv Kumar, Safia May Farry, Mark Ezegbogu et al.· JMIR Research Protocols· 0 citations
This review synthesizes current advances in CRISPR-based DNA methylation editing for cancer epigenomics, critically evaluates key challenges, including off-target activity, context-dependent outcomes, delivery and durability, and outlines future directions integrating locus-specific editing with multi-omics profiling,...
Negar Sadeghi, E. Rodger, Aniruddha Chatterjee· Cellular and Molecular Life...· 0 citations
The molecular landscape of prostate cancer is discussed, before providing a detailed overview of the molecular approaches available for early detection and prognostication and highlighting areas of future research.
A. Yee, Jim Smith, Rajiv Kumar et al.· Cancer Metastasis Review· 0 citations
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