Importance Psychiatric disorders are a major source of disability and premature mortality worldwide. Advances in genomics have clarified parts of their genetic architecture, prompting questions about whether genomic information can inform preventive strategies for psychiatric disorders in clinical practice. In this Per...
K. Musliner, Eva C. Schulte, G. Breen et al.· JAMA psychiatry· 0 citations
There is promise in pathway-level and multi-omics approaches to elucidate biologically meaningful heterogeneity within SSD and support for synaptic mechanisms as potential targets for understanding and stratifying treatment-resistance is provided.
P. B. Leung, K. C. Wong, S. Smart et al.· medRxiv· 0 citations
Findings provide proof-of-concept for the utility of pPGSs in psychiatric research, suggesting both genetic contributions to trauma exposure and GxE effects on psychosis risk, as well as supporting pathway-specific contributions beyond general polygenic risk.
G. Trotta, I. Austin-Zimmerman, E. Spinazzola et al.· Translational Psychiatry· 0 citations
Prolonged CAL is linked to higher risk of FEP, preferentially affective psychosis in females, poorer functioning, and developmental potentiation of polygenic liability.
Á. Andreu-Bernabeu, J. González-Peñas, M. Bernardo et al.· Schizophrenia bulletin· 0 citations
In the largest electronic health records study of 22q11.2DS to date, a profound neuropsychiatric burden is revealed and the potential of routinely collected health data to advance understanding of rare disorders is demonstrated.
C. Watson, M. Rogdaki, K. Lynch-Kelly et al.· medRxiv· 0 citations
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