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Prolonged Childhood and Adolescent Loneliness in First-Episode Psychosis: Synergistic Polygenic Effects and Functional Outcomes.

Á. Andreu-Bernabeu J. González-Peñas M. Bernardo S. Amoretti J. Bobes M. Arrojo M. Parellada Michael C. O'Donovan J. van Os B. Rutten R. Murray M. di Forti E. Vassos C. Arango C. Díaz-Caneja
Aug 2026 · Schizophrenia bulletin · Vol 52 5 · 0 citations
Medicine

TL;DR

Prolonged CAL is linked to higher risk of FEP, preferentially affective psychosis in females, poorer functioning, and developmental potentiation of polygenic liability.

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