Author

Elena Garralda

2 papers indexed here

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Clinical trial Open access Sep 2026

Phase 1/1b open-label, first-in-human study of HER2×CD3×CD28 trispecific T-cell engager (SAR443216) in participants with R/R HER2-expressing solid tumors

Abstract Background SAR443216 is an engineered human trispecific antibody that targets human epidermal growth factor receptor 2 (HER2)-positive (HER2+) cancer cells and activates T cells via co-engagement of cluster of differentiation (CD)3 and CD28. This first-in-human, dose-escalation study evaluated the safety, effi...

E. Dumbrava, Do-Youn Oh, Min-Hee Ryu et al. · Journal for ImmunoTherapy of... · 0 citations

Open access Sep 2026

Peripheral Blood as the Sole Source for Cancer Neoantigen and Reactive T-Cell Discovery.

Neoantigen-targeted T-cell therapies require invasive tumor biopsies to identify neoantigens and reactive T cells, limiting their applicability and potentially underestimating tumor heterogeneity. We propose a novel strategy relying solely on peripheral blood to identify non-synonymous mutations via cell-free DNA whole...

Andrea García-Garijo, I. Creus-González, Pierre L. Levy et al. · Cancer Discovery · 0 citations