Order–disorder interfaces in viral pRb inactivation: molecular dynamics insights into SLiM-mediated recognition and implications for interaction databases
Intrinsically disordered regions (IDRs) mediate protein interactions through poorly understood mechanisms. We studied the retinoblastoma protein (pRb) and its interaction with the SV40 Large T antigen (LTSV40), a viral oncoprotein that displaces E2F factors. Using molecular dynamics and umbrella sampling, we show the L...
Carla Luciana Padilla Franzotti, Nicolás Palópoli, Gustavo Pierdominici‐Sottile et al.
· Zenodo (CERN European Organi... · 0 citations