Hybrid lipid-nanogels: nanolipogels for mRNA delivery
NLGs are a hybrid phospholipid-polymer carrier built around a synthetic phospholipid, phosphatidylbutenol synthesised in a single enzyme-catalysed transphosphatidylation step from 1,2-dioleoyl-sn-glycero-3-phosphocholine, and exhibit sustained mRNA release over seven days in the presence of 10 mM glutathione.