Cyclic tri-adenylate controls a CARF-TM effector in type II Panoptes anti-phage systems
The type II Panoptes system is investigated, demonstrating that it generates cyclic tri-adenylate (cA3) to maintain a CRISPR-associated Rossmann fold-transmembrane (CARF-TM) effector in an inactive, dimeric state.
S. Grüschow, Peter Wotherspoon, Emma Hilton-Balfe et al.
· PLoS Biology · 1 citation
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