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Sponsored AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI

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Eun-Hye Seo

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Review Open access Oct 2026

Self-Amplifying RNA Vaccines After the First Approvals: Technology, Development Landscape, and Regulatory Science Considerations

Self-amplifying RNA (saRNA) is a next-generation nucleic acid vaccine platform that enhances antigen expression through intracellular amplification of replicon RNA without producing infectious virions. saRNA constructs encode an alphavirus-derived replicase comprising nonstructural proteins nsP1–nsP4 and can elicit rob...

Sung-Yun Yi, Eun-Hye Seo, Kee-Jong Hong et al. · 0 citations
#gene editing Review Open access Oct 2026

From prophylactic mRNA vaccines against viral infections to therapeutic applications: regulatory science considerations for expanding mRNA platforms

Conventional non-amplifying messenger RNA (mRNA) and self-amplifying RNA (saRNA) medicines generally share a core linear RNA architecture—including a 5′ cap, untranslated regions, one or more open reading frames, and a poly(A) tail—and are commonly formulated with delivery systems such as lipid nanoparticles (LNPs) t...

Sung-Yun Yi, Eun-Hye Seo, Pil-Gu Park et al. · 0 citations

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