Oncogene activation mechanism determines the limits of targeted protein degradation.
This work developed orthogonal methods to increase production or enhance stability of β-catenin, an important oncoprotein and target for degrader therapeutics, and used the dTAG system to evaluate the consequences for PROTAC activity.
Evelina Gudauskaitė, Brianda Hernández-Morán, Gillian C. A. Taylor et al.
· Cell Chemical Biology · 0 citations