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Author

F. Zipp

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Open access Sep 2026

Genome-wide association analyses highlight the neuronal contribution to multiple sclerosis susceptibility

Inhibitory neurons emerged as a key target cell type for MS-associated variants, with seven loci, including STAT3, displaying altered expression only in these cells, suggesting that MS susceptibility may reflect reduced central nervous system resilience to inflammatory challenges.

Lu Zeng, Atlas Khan, Kathryn C. Fitzgerald et al. · 0 citations
Review Aug 2026

Immune-mediated excitotoxicity in brain disorders.

The concept of excitotoxicity is extended beyond glutamate receptor overactivation to include innate and adaptive immune pathways, introducing the framework of immune-mediated excitotoxicity and defining three hallmarks - feedback, stressor and chronicity - as organizing principles of this paradigm.

Josef Shin, C. Vogelaar, Stefan Bittner et al. · 0 citations

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