Aug 2026· Nature reviews. Immunology· 0 citations· 152 references
Medicine
TL;DR
The concept of excitotoxicity is extended beyond glutamate receptor overactivation to include innate and adaptive immune pathways, introducing the framework of immune-mediated excitotoxicity and defining three hallmarks - feedback, stressor and chronicity - as organizing principles of this paradigm.
The mechanisms linking systemic inflammation to brain dysfunction are evaluated and emerging translational opportunities are highlighted, including the therapeutic repurposing of cytokine-targeting and immunomodulatory agents for neuropsychiatric interventions.
Ye-Lin Lee, Jaewon Ko, J. Um· Experimental and Molecular M...· 0 citations
Intervention strategies that shift from targeting peripheral immune and glial cells to regulating neuron-derived immunity are systematically integrated, thereby providing a new theoretical framework for overcoming current clinical limitations and identifying effective therapeutic targets for the prevention and treatmen...
Jie Bu, Xuan Nie, Haiting Luo et al.· Pharmacological Research· 0 citations
Robust data support a model in which neurodegeneration emerges from complex interactions between neural and immune networks, positioning the immune system as both a sensor and driver of brain health and a deeper integration of neuroscience and immunology could transform the future of treating neurodegenerative diseases...
F. C. Bennett, Soyon Hong, Ning Jiang et al.· Cell· 0 citations
This framework suggests that effective therapeutic strategies may require restoration of physiological regulatory networks rather than targeting individual neurotoxic molecules in isolation, and facilitates the development of earlier biomarkers and more effective interventions aimed at preserving neuronal homeostasis a...
Sangeeta Yanglem, Borish Loushambam, Sorokhaibam Mexico Singh et al.· Neuroglia· 0 citations
This review synthesizes current evidence on the biochemistry of the glutamatergic synapse, as well as the expression and signaling of Glu receptors in human immune cells, and proposes a unified glutamatergic–neuroimmune framework.
Nikolaos A. Chinas, Harry Alexopoulos· Cellular and molecular neuro...· 0 citations
This framework integrates immune mechanisms, glial-synaptic interactions, and network-level dysfunction into a unified pathogenic continuum and explains why interventions targeting only a single aspect, such as immunotherapy or surgical seizure control alone, consistently fail to halt disease progression.
Yu-Jie Bo, Chong-Yang Tang, Xiong-Fei Wang et al.· Autoimmunity Reviews· 0 citations
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