As a common clinical syndrome with high morbidity and mortality, acute kidney injury (AKI) involves epigenetic mechanisms that remain largely uncharacterized. In this study, we identify a previously uncharacterized long non-coding RNA mmu-lncR-gm33782 and its human homolog hsa-lncR-CLLU1-AS1 as a critical epigenetic dr...
Rui-Zhi Tan, Jian Jia, Qiu-Xiang Bai et al.· International Journal of Bio...· 0 citations
Kidney diseases, represented by chronic kidney disease (CKD) and acute kidney injury (AKI), pose significant global public health challenges due to their complex pathogenesis and limited therapeutic options. In recent years, epigenetic regulation-including DNA methylation, histone modifications, and non-coding RNAs-has...
Qiu-xiang Bai, Kang Luo, Long-hao Jia et al.· Seminars in Nephrology· 0 citations
Traditional human blood vessel organoids, built primarily around endothelial monocultures, fail to replicate the multicellular architecture and dynamic immunological functions of native microvasculature. This review synthesizes an emerging paradigm shift toward third-generation, multi-lineage, and immune-competent vasc...