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Aug 2026

CD276 promotes lipid metabolic reprogramming and regulates ferroptosis in clear cell renal cell carcinoma by upregulating FASN expression via SREBP1

The pivotal role of the CD276–SREBP1–FASN axis in regulating lipid metabolism and ferroptosis in ccRCC is revealed, providing a theoretical basis for CD276-targeted therapy combined with ferroptosis induction as a treatment strategy for ccRCC.

Zhi-Yu Zhang, Fan Zhang, Yanhang Yu et al. · 0 citations

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