Aug 2026· Human Cell· Vol 39· 0 citations· 44 references
Medicine
TL;DR
The pivotal role of the CD276–SREBP1–FASN axis in regulating lipid metabolism and ferroptosis in ccRCC is revealed, providing a theoretical basis for CD276-targeted therapy combined with ferroptosis induction as a treatment strategy for ccRCC.
Metabolic reprogramming, particularly dysregulated lipid metabolism, is a hallmark of clear cell renal cell carcinoma (ccRCC) progression. However, the upstream regulators responsible for lipid metabolic rewiring remain largely unknown. Here, we integrated single-cell RNA sequencing, spatial transcriptomics, and functi...
Ashuai Du, Ke-Hua Jiang, Kai Li et al.· Cancer Letters· 0 citations
A conceptual framework for understanding HDL-centered cholesterol metabolism in ccRCC is provided and potential metabolic vulnerabilities for therapeutic targeting are highlighted and outlined.
It is demonstrated that PSMD11 was markedly upregulated in HCC tissues and correlated with poor patient prognosis, and a PSMD11–PSMD14–SREBP1/2-PPAR-γ–CPT1A regulatory axis that orchestrates metabolic reprogramming in HCC is uncovered.
Zhi-Hong Huang, Can-Xue Zhang, Chi Zhang et al.· Cell Death & Disease· 0 citations
Ferroptosis of NK cells may be an important mechanism connecting tumor metabolic reprogramming and immune dysfunction, and is expected to become a new direction for immunotherapy intervention.
Previous work has indicated that lipid metabolic reprogramming plays a critical role in gastric cancer (GC) development, yet the underlying molecular mechanisms remain largely undefined. In the present study, we identified a novel lipid metabolism-associated long non-coding RNA, 3-Hydroxy-3-Methylglutaryl-CoA Synthase...
Qiang Yang, Yu-Yang He, Le-Jia Wang et al.· European Journal of Pharmaco...· 0 citations
Ferroptosis is a non‐apoptotic form of programmed cell death driven by iron‐dependent lipid peroxidation. Induction of ferroptosis has been shown to overcome chemoresistance in cancer cells. Given the importance of the nuclear factor erythroid 2‐related factor 2 (NRF2) pathway in the regulation of cellular oxidative st...
Guang-Zeng Zhou, Zhuo-Hang Zhu, Hong-Li Liao et al.· Journal of cell communicatio...· 0 citations
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