Metabolic-epigenetic regulation of the HBV cccDNA reservoir: pathways underpinning viral persistence
Chronic hepatitis B virus (HBV) infection remains a global public health burden, and functional cure represents the primary goal of clinical management. The nuclear covalently closed circular DNA (cccDNA) minichromosome stably maintained in infected hepatocytes constitutes the major barrier to HBV cure. Clinically, f...
Qing Peng, Li-Yuan Hao, Sheng-Hao Li et al.
· Frontiers in Microbiology · 0 citations