Author

Feng Zhu

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#gene editing Open access Oct 2026

Severity-dependent and sex-biased dysregulation of A-to-I RNA editing in COVID-19 reveals CTSS as a key regulatory target

ABSTRACT SARS-CoV-2 infection causes diverse clinical outcomes, with men facing higher risks of severe disease. Adenosine-to-inosine (A-to-I) RNA editing mediated by ADAR enzymes governs innate antiviral immunity, yet its contribution to COVID-19 severity and sex-biased disease remains unclear. We performed epitranscri...

Jing-Yuan Wang, Ya-Di Zhao, Li-Ping Wang et al. · RNA Biology · 0 citations

Aug 2026

TRIM32 regulates Mycobacterium tuberculosis-induced pyroptosis and mitochondrial dysfunction by regulating TLR4 ubiquitylation.

Tuberculosis (TB), caused by Mycobacterium tuberculosis (M.tb), remains a major global health threat. The tripartite motif (TRIM) family of E3 ligases plays crucial roles in various cellular processes, yet the involvement of TRIM32 in TB remains poorly understood. This study explores the function of TRIM32 in M.tb infe...

Wei Zhao, Tiantian Zhang, Meng Hua et al. · Acta Histochemica · 0 citations