Aortic disease-linked mutations reveal unexpected convergent allosteric mechanisms of protein kinase G misregulation
Using NMR, molecular dynamics simulations, and complementary kinase and binding assays, it is shown that Val234 acts as a crucial allosteric hub of PKG autoinhibition, explaining how distal mutations can unpredictably rewire kinase allostery and drive pathogenic vascular signaling.
Karla Martinez Pomier, Leopold Jahn, B. VanSchouwen et al.
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