Author

Fyodor D. Urnov

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Open access Aug 2026

Reprogramming Cas9 PAM Recognition for Allele-Specific Editing

A yeast selection platform is developed to engineer Cas9 with re-specified activity across multiple additional non-canonical PAMs in yeast, further demonstrating its utility as a general and programmable framework for expanding the therapeutic reach of precision genome editing.

Julia Tartaglia, Vivian Nguyen, John James Desmarais et al. · bioRxiv · 0 citations

#gene editing Open access Aug 2026

A Toolbox for Binary and Rheostat-like Modulation of TOX Expression via Genome and Epigenome Editing in Primary Human T cells

These studies show that a complete TOX knockout or silencing has no effect on exhaustion marker expression levels or the transcriptome in repeat-anti-CD3/anti-CD28-stimulated primary human T cells in vitro.

Elaine V. Schanzer, Katharine F. Vostrejs, Alexandra N. Kurciska et al. · bioRxiv · 0 citations