Author

G. Casirati

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Review Open access Jul 2026

Editing around the target: epitope engineering to protect stem cell grafts

Collectively, epitope engineering of hematopoietic stem cells represents a versatile platform to expand the therapeutic window of precision immunotherapies and may enable safer, more effective combinatorial treatment strategies for both nonmalignant and malignant hematologic conditions.

Joanne Baek, G. Casirati, Pietro Genovese et al. · Blood Advances · 0 citations

Open access Jul 2026

Non-genotoxic transplantation and in vivo selection through epitope editing

Epitope editing of KIT enables antibody-based, non-genotoxic conditioning that selectively enriches therapeutic BCL11A-edited haematopoietic stem/progenitor cells, supports durable engraftment, preserves clonal diversity and enhances induction of fetal haemoglobin, a therapeutic approach for conditions such as sickle c...

G. Casirati, Andrea Cosentino, Marta Freschi et al. · Nature · 0 citations

Open access Aug 2026

Functional restoration of immune defects in STAT1 gain-of-function disease following stem cell gene editing.

Efficient and precise correction of STAT1 GOF mutations by base editing is demonstrated, with maintenance of the correction through long-term engraftment in vivo, which represents the first application of gene editing to correct a dominant gain-of-function mutation causing immunodeficiency.

Robert Torrance, K. Orf, Nathan White et al. · Blood · 0 citations