Author

G. Rani

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Review Open access Aug 2026

GAUCHER`S DISEASE: DIAGNOSIS, ENZYME REPLACEMENT THERAPY, AND PHARMACEUTICAL FORMULATIONS IN TREATMENT– A COMPREHENSIVE REVIEW

Gaucher's disease (GD) is the most common lysosomal storage disorder caused by mutations in the GBA1 gene, resulting in deficiency of the enzyme β-glucocerebrosidase. This leads to the accumulation of glucosylceramide within macrophages, causing progressive involvement of the liver, spleen, bone marrow, and, in severe...

K. Deepthi, S. Bhargavi, G. Rani et al. · Genetics and Molecular Resea... · 0 citations

Review

Design and in Vitro Neuroprotective Evaluation of Pyrimidine-Based Compounds for Alzheimer’s Therapy

This review highlights the pyrimidine scaffold as a privileged structure in medicinal chemistry for the development of neuroprotective agents, and details the evolution from single-target to multi-target design, focusing on hybrid molecules and metal.

V. Sharma, G. Rani, S. Rai et al. · 0 citations