This review highlights the pyrimidine scaffold as a privileged structure in medicinal chemistry for the development of neuroprotective agents, and details the evolution from single-target to multi-target design, focusing on hybrid molecules and metal.
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder characterized by amyloid-beta aggregation, tau pathology, oxidative stress, neuroinflammation, mitochondrial dysfunction, and synaptic degeneration. The limited clinical success of traditional single-target therapeutic approaches has highlighted th...
Renu Yadav, Jyoti Sinha, Km Deeksha· Central Nervous System Agent...· 0 citations
This review comprehensively summarizes and critically analyzes advances reported from 2020 to 2026 in the design, synthesis, biological evaluation, and therapeutic potential of RIV-based hybrid molecules and scaffold modifications for AD treatment.
Nitin Kumar, V. Kushwaha, Gourav Singh et al.· Bioorganic & Medicinal Chemi...· 0 citations
Parkinson's disease (PD) is a debilitating and progressive neurodegenerative disorder, where disease-modifying therapy (DMT) represents a major unmet clinical need. Advances in the understanding of underlying pathogenesis reveal the potential therapeutic value of inhibitors targeting leucine-rich repeat kinase 2 (LRRK2...
Wen-Qing Xu, Tian-Qiang Liu, Xin-Yuan Miao et al.· European journal of medicina...· 0 citations
The abnormal aggregation of amyloid-beta (Aβ) peptides is a core driver of Alzheimer’s disease (AD). Developing central nervous system (CNS)-penetrant small-molecule Aβ inhibitors offers a complementary strategy to overcome the high costs and severe side effects of antibodies. Lanosterol has demonstrated excellent po...
Bai-Chen Xiong, Teng-Fei Zhen, Xin-Hai Wang et al.· Journal of Medicinal Chemist...· 0 citations
Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder and the leading cause of dementia among the elderly worldwide. In medicinal chemistry and drug discovery, heterocycles are widely recognized as privileged scaffolds due to their structural versatility and biological relevance. In the context of AD,...
Daniela Malafaia, Lúcia Melo, Artur M. S. Silva et al.· ChemMedChem· 0 citations
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder involving mainly cholinergic dysfunction, protein misfolding, and metal dyshomeostasis. Considering the complexity of the pathology, multi-target approaches represent a valuable alternative to current approved mono-target treatments. In this study,...
Marco Paparella, R. Leuci, Marco Cerini et al.· Bioorganic chemistry (Print)· 0 citations
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