Abstract We present the first spatial tri-omic (proteomic, transcriptomic, and epigenomic) taxonomy of human hippocampus, addressing two key challenges in single-cell and spatial transcriptomics: visualizing cell morphology and epigenetic gene regulation in situ. By designing and multiplex imaging a novel panel of 25 p...
Rong Fan, Yang Xiao, Graham Su et al.· Research Square· 0 citations
Proteomics and transcriptomics convergent dysregulations in MDD, point to lipid metabolism, neurogenesis, synaptogenesis, cell adhesion, cell adhesion, and plasticity.
Madeline B. Mariani, Anthony D. Ramnauth, Xiao Yang et al.· 0 citations
A neurogenic lineage in the adult human hippocampal subgranular zone is identified and evidence for a stalled neurogenic process in MDD is provided, associated with transcriptional regulation, stress-related reprogramming and interferon signaling across developmental stages.
Madeleine S Peng, Jia-Jia Jiang, Luciana Polizzi et al.· Nature Medicine· 2 citations
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