Proteomics and transcriptomics convergent dysregulations in MDD, point to lipid metabolism, neurogenesis, synaptogenesis, cell adhesion, cell adhesion, and plasticity.
A neurogenic lineage in the adult human hippocampal subgranular zone is identified and evidence for a stalled neurogenic process in MDD is provided, associated with transcriptional regulation, stress-related reprogramming and interferon signaling across developmental stages.
Madeleine S Peng, Jia-Jia Jiang, Luciana Polizzi et al.· Nature Medicine· 2 citations
The pathophysiology of depression involves multiple biological processes, including circuit dysfunction and impaired neuroplasticity, yet an integrative view linking these processes remains elusive. Here, we identify a convergent circuit for antidepressant response and plasticity modulation. We demonstrate that chemoge...
M. Veleanu, Louise Schuberth, Antje Kilias et al.· Nature Communications· 0 citations
These findings connect MDD polygenic risk to motor-cortical inhibitory-neuron biology and experimentally tractable circuit mechanisms and provide scDepBrain as a resource for exploring MDD-associated cellular programs across the brain.
Y. Ma, H. Han, C. Chen et al.· medRxiv· 0 citations
It is demonstrated that Ddit4 overexpression specifically in neurons is sufficient to reduce spine density in the PFC, impair temporal order memory, and induce transcriptional changes associated with stress and depression.
Alexander M. Kuhn, Kelly E. Bosis, Madeline M. Mairose et al.· eNeuro· 0 citations
Stress is a major risk factor for depression- and anxiety-related disorders and produces neuroplastic adaptations within brain regions that regulate emotion, cognition, and stress responsivity. These adaptations include dendritic retraction in the medial prefrontal cortex (mPFC), suppression of plasticity and neurogene...
Alexa C. E. Alcala, Sophia C. Bellitire, Katherine E. Brunson et al.· Frontiers in Psychiatry· 0 citations
A timely and comprehensive view of the anterior cingulate cortex’s role in adaptive and pathological anxiety is provided and an integrative model in which ACC effects depend on subregion, projection target, and behavioral context is proposed.
Emily Dew, Alexis Jones, S. Saggu et al.· Frontiers in Psychiatry· 0 citations
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