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Review Sep 2026

Beyond the Apnea-Hypopnea Index: A Pathophysiological and Phenotypic Approach to Personalized Treatment in Obstructive Sleep Apnea

This narrative review summarizes the major symptom-based and polysomnographic phenotypes of OSA, examines their association with the underlying physiological traits, and considers the implications for treatment selection.

Uygur Tanrıverdi, G. Şenel · 0 citations
Open access Aug 2026

Physiological Signatures Derived from Wrist Accelerometry Improve Detection of Isolated REM Sleep Behavior Disorder

Isolated REM sleep behavior disorder (iRBD) is the strongest prodromal marker of -synucleinopathies, but polysomnography is impractical for population-scale screening and questionnaires lack sufficient specificity. Beyond nocturnal movement, recently published models can derive sleep staging and other physiological sig...

A. Brink-Kjaer, Johanne Niman Abildgaard, N. Lorenzen et al. · 0 citations
Jul 2026

Serum hypoxia-inducible factors, heat shock proteins, and mitochondrial biomarkers in relation to neurocognitive performance in obstructive sleep apnea: a cross-sectional study.

The authors' results demonstrated complex and important correlations between neurocognitive assessments and mediators of hypoxia, inflammation, protein misfolding, and mitochondrial trafficking, which may serve as biochemical biomarkers of cognitive impairment in OSA.

G. Şenel, Pelin Sordu, M. Sahin et al. · 0 citations

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